Hypertension and atherosclerosis are among the most common causes of mortality in both developed and developing countries.\nExperimental animalmodels of hypertension and atherosclerosis have becomea valuable tool for providing information on etiology,\npathophysiology, and complications of the disease and on the efficacy and mechanism of action of various drugs and compounds\nused in treatment. An animal model has been developed to study hypertension and atherosclerosis for several reasons. Compared\nto human models, an animal model is easily manageable, as compounding effects of dietary and environmental factors can be\ncontrolled. Blood vessels and cardiac tissue samples can be taken for detailed experimental and biomolecular examination. Choice\nof animal model is often determined by the research aim, as well as financial and technical factors. A thorough understanding of\nthe animal models used and complete analysis must be validated so that the data can be extrapolated to humans. In conclusion,\nanimal models for hypertension and atherosclerosis are invaluable in improving our understanding of cardiovascular disease and\ndeveloping new pharmacological therapies.
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